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Home » R & D » Nutritional research » Evolus® Double Effect

For the health of the heart

Evolus® Double Effect products help lower cholesterol and control blood pressure thanks to the bioactive tripeptides and plant sterol they contain, combined with the beneficial mineral composition of milk. Isoleucine-proline-proline (IPP) and valine-proline-proline (VPP) tripeptides are created when milk protein is degraded into smaller components during the Valio Evolus® Double Effect products' fermentation process using Valio's patented method. The peptides help control blood pressure by inhibiting the action of the blood-pressure-increasing angiotensin converting enzyme (ACE). The products' mineral composition with little sodium but plenty of calcium and potassium is also beneficial for blood pressure.

The plant sterol added to Valio Evolus® Double Effect products lower total cholesterol and harmful LDL cholesterol, without affecting beneficial HDL cholesterol. The efficacy of the effective agents in Valio Evolus® Double Effect products has been verified in clinical studies.

Valio is licensing the technology and invites applications.

Contact person is Ms. Maritta Timonen,
tel. + 358 10381 2035.

List of references concerning Evolus® studies (pdf)
Effects of milk products and milk protein-derived peptides on blood pressure and arterial function in rats (doctoral dissertation, pdf)
Blood pressure lowering effects of Lactobacillus helveticus fermented milk containing bioactive peptides Ile-Pro-Pro and Val-Pro-Pro: mechanistic, kinetic and clinical studies (doctoral dissertation, pdf)
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